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Q: Disseminated Intravascular Coagulation (DIC)

Disseminated intravascular coagulation is a critical condition that can cause both thrombosis and bleeding at the same time. Why do these two contradictory symptoms happen simultaneously?
DIC is induced by sepsis (infection occurs throughout the body) or cancer ,especially an acute promyelocytic leukemia (APL). These underlying diseases result in an imbalance between coagulation and fibrinolysis. Sepsis or cancer leads overproduction of tissue factor (TF) throughout the body. TF encourages coagulation of blood and makes many microthrombus. These microthrombus can cause infarction and ischemia of brain, lung, heart and many other organs.
After the thrombosis around the body, the body try to solve the situation and encourage fibrinolysis (a process that prevents blood clots from growing). The overreactive fibrinolysis results in bleeding in brain, lung and digestive tract.
For the treatment of DIC, the patient will be administered anticoagulant agent and replacement therapy (eg, platelets, cryoprecipitate, fresh frozen plasma) but the most important treatment is treatment of cause. sembra naturale?

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