Che cosa significa "To co?" ?

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I would say it depends on context but generally "To co?" means "So what?"/"What of it?". We can also say "(No) i co z tego?" and it has the same meaning as "To co?". I think it will make more sense if I show it using certain examples, so here they are:
1) - Tomek zachorował i leży w szpitalu. - Tom has become ill and he's in hospital.
* To co?/I co z tego? Nie za bardzo mnie to interesuje. - What of it? I don't really care.

2) - Kasiu, ostatnio dostajesz same słabe oceny. - Kate, you've been getting only bad grades at school recently.
* To co?/No i co? Nie muszę być prymusem. Nie lubię szkoły. - So what? I don't have to be a top student. I don't like school.

In conclusion, using "To co?"/"No i co z tego?" we mean "I don't care! Why you even telling me this?"